Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1
Identifieur interne : 001C38 ( Main/Exploration ); précédent : 001C37; suivant : 001C39Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1
Auteurs : Nebojša M. Lali [Serbie] ; Nataša Dragaševi [Serbie] ; Elka Stefanova [Serbie] ; Aleksandra Joti [Serbie] ; Katarina Lali [Serbie] ; Tanja Mili I [Serbie] ; Igor Petrovi [Serbie] ; Marija Ma Eši [Serbie] ; Vladimir S. Kosti [Serbie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Cholesterol, LDL.
- chemical , metabolism : Blood Glucose, Insulin.
- chemical , secretion : Insulin.
- metabolism : Spinocerebellar Ataxias.
- Glucose Clamp Technique, Glucose Tolerance Test, Humans, Insulin Resistance.
Abstract
We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD‐specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA‐insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23176
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000761
- to stream Istex, to step Curation: 000761
- to stream Istex, to step Checkpoint: 000917
- to stream PubMed, to step Corpus: 001689
- to stream PubMed, to step Curation: 001689
- to stream PubMed, to step Checkpoint: 001834
- to stream Ncbi, to step Merge: 002D28
- to stream Ncbi, to step Curation: 002D28
- to stream Ncbi, to step Checkpoint: 002D28
- to stream Main, to step Merge: 002074
- to stream Main, to step Curation: 001C38
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1</title><author><name sortKey="Lali, Nebojsa M" sort="Lali, Nebojsa M" uniqKey="Lali N" first="Nebojša M." last="Lali">Nebojša M. Lali</name></author><author><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Nataša" last="Dragaševi">Nataša Dragaševi</name></author><author><name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name></author><author><name sortKey="Joti, Aleksandra" sort="Joti, Aleksandra" uniqKey="Joti A" first="Aleksandra" last="Joti">Aleksandra Joti</name></author><author><name sortKey="Lali, Katarina" sort="Lali, Katarina" uniqKey="Lali K" first="Katarina" last="Lali">Katarina Lali</name></author><author><name sortKey="Mili I, Tanja" sort="Mili I, Tanja" uniqKey="Mili I T" first="Tanja" last="Mili I">Tanja Mili I</name></author><author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name></author><author><name sortKey="Ma Esi, Marija" sort="Ma Esi, Marija" uniqKey="Ma Esi M" first="Marija" last="Ma Eši">Marija Ma Eši</name></author><author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S." last="Kosti">Vladimir S. Kosti</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1CB91F429E3A4A34BAE56F764EEC759C4AFB0DC1</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23176</idno><idno type="url">https://api.istex.fr/document/1CB91F429E3A4A34BAE56F764EEC759C4AFB0DC1/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000761</idno><idno type="wicri:Area/Istex/Curation">000761</idno><idno type="wicri:Area/Istex/Checkpoint">000917</idno><idno type="wicri:doubleKey">0885-3185:2010:Lali N:impaired:insulin:sensitivity</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:20669273</idno><idno type="wicri:Area/PubMed/Corpus">001689</idno><idno type="wicri:Area/PubMed/Curation">001689</idno><idno type="wicri:Area/PubMed/Checkpoint">001834</idno><idno type="wicri:Area/Ncbi/Merge">002D28</idno><idno type="wicri:Area/Ncbi/Curation">002D28</idno><idno type="wicri:Area/Ncbi/Checkpoint">002D28</idno><idno type="wicri:Area/Main/Merge">002074</idno><idno type="wicri:Area/Main/Curation">001C38</idno><idno type="wicri:Area/Main/Exploration">001C38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1</title><author><name sortKey="Lali, Nebojsa M" sort="Lali, Nebojsa M" uniqKey="Lali N" first="Nebojša M." last="Lali">Nebojša M. Lali</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Nataša" last="Dragaševi">Nataša Dragaševi</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute of Neurology, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute of Neurology, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Joti, Aleksandra" sort="Joti, Aleksandra" uniqKey="Joti A" first="Aleksandra" last="Joti">Aleksandra Joti</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Lali, Katarina" sort="Lali, Katarina" uniqKey="Lali K" first="Katarina" last="Lali">Katarina Lali</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Mili I, Tanja" sort="Mili I, Tanja" uniqKey="Mili I T" first="Tanja" last="Mili I">Tanja Mili I</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute of Neurology, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Ma Esi, Marija" sort="Ma Esi, Marija" uniqKey="Ma Esi M" first="Marija" last="Ma Eši">Marija Ma Eši</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S." last="Kosti">Vladimir S. Kosti</name><affiliation wicri:level="1"><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute of Neurology, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15">2010-09-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1976">1976</biblScope><biblScope unit="page" to="1980">1980</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1CB91F429E3A4A34BAE56F764EEC759C4AFB0DC1</idno><idno type="DOI">10.1002/mds.23176</idno><idno type="ArticleID">MDS23176</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Glucose (metabolism)</term><term>Cholesterol, LDL (blood)</term><term>Glucose Clamp Technique</term><term>Glucose Tolerance Test</term><term>Humans</term><term>Insulin (metabolism)</term><term>Insulin (secretion)</term><term>Insulin Resistance</term><term>Spinocerebellar Ataxias (metabolism)</term><term>insulin resistance</term><term>spinocerebellar ataxia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Glucose Clamp Technique</term><term>Glucose Tolerance Test</term><term>Humans</term><term>Insulin Resistance</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD‐specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA‐insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Serbie</li></country></list><tree><country name="Serbie"><noRegion><name sortKey="Lali, Nebojsa M" sort="Lali, Nebojsa M" uniqKey="Lali N" first="Nebojša M." last="Lali">Nebojša M. Lali</name></noRegion><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Nataša" last="Dragaševi">Nataša Dragaševi</name><name sortKey="Joti, Aleksandra" sort="Joti, Aleksandra" uniqKey="Joti A" first="Aleksandra" last="Joti">Aleksandra Joti</name><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S." last="Kosti">Vladimir S. Kosti</name><name sortKey="Lali, Katarina" sort="Lali, Katarina" uniqKey="Lali K" first="Katarina" last="Lali">Katarina Lali</name><name sortKey="Ma Esi, Marija" sort="Ma Esi, Marija" uniqKey="Ma Esi M" first="Marija" last="Ma Eši">Marija Ma Eši</name><name sortKey="Mili I, Tanja" sort="Mili I, Tanja" uniqKey="Mili I T" first="Tanja" last="Mili I">Tanja Mili I</name><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name><name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C38 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C38 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1CB91F429E3A4A34BAE56F764EEC759C4AFB0DC1
|texte= Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1
}}
| This area was generated with Dilib version V0.6.23. |  |